BLOOD PRESSURE MEASUREMENT IN RATS USING THE TAIL-CUFF METHOD

Authors

  • R. Z. Saydaliyeva 1Assistant, Department of Medical Chemistry and Biological Sciences, Central Asian Medical University, Author
  • A. E. Zaynabiddinov 2 Professor, Doctor of Biological Sciences Andijan State University, Uzbekistan Author

Keywords:

Polyphenols, Flavonoids, Natural Antioxidants, Signal Transduction, Wistar Rats, Systolic Blood Pressure

Abstract

Neurodegenerative disorders are often exacerbated by vascular dysregulation and oxidative stress. Polyphenols have emerged as potent bioactive compounds capable of modulating molecular signaling pathways to preserve neuronal integrity. However, maintaining systemic physiological parameters, such as systolic blood pressure (SBP), is crucial for ensuring the efficacy of these neuroprotective agents.

References

1. Lipscombe, Diane & Helton, Thomas & Xu, Weifeng. (2004). L-Type Calcium Channels: The Low Down. Journal of neurophysiology. 92. 2633-41. 10.1152/jn.00486.2004

2. Cataldi, Mauro. (2016). BAY-K 8644. 10.1016/B978-0-12-801238-3.99378-4

3. J Duarte, R Pérez‐Palencia, F Vargas, MA Ocete, F Pérez-Vizcaino, A Zarzuelo and J Tamargo. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British Journal of Pharmacology 2001; 133(1), 117-124

4. M Fritz and G Rinaldi. Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: Influence of adrenergic- and nitric oxide-mediated vasomotion. Journal of Pharmacological and Toxicological Methods 2008; 58(3), 215-221

Published

2026-03-31