LEYKOTSIT DISFUNKTSIYASI, ENDOTELIAL SHIKASTLANISH VA YALLIG‘LANISHDAN TOMIR DEVORI QAYTA QURILISHIGACHA BO‘LGAN PATOLOGIK JARAYONLARNING INTEGRATSIYASI
Keywords:
Leykotsit disfunktsiyasi, endotelial disfunksiya, yallig‘lanish, vaskulyar remodeling, tomir infiltratsiyasi, sitokinlar, matriks metalloproteinazalar, ateroskleroz, NLRP3 inflammasoma, NF-κB.Abstract
So‘nggi o‘n yil ichida kardiovaskulyar patologiyalarning molekulyar va hujayraviy mexanizmlarini o‘rganish bo‘yicha olib borilgan tadqiqotlar shuni ko‘rsatdiki, leykotsit disfunktsiyasi, endotelial shikastlanish va yallig‘lanish jarayonlari o‘rtasidagi o‘zaro bog‘liqlik tomir devorining patologik qayta qurilishi (vaskulyar remodeling) va ateroskleroz, arterial gipertenziya, yurak yetishmovchiligi kabi ko‘plab kasalliklarning rivojlanishida markaziy rol o‘ynaydi [1,2]. Bu sharhli maqola 2015-2025-yillarda chop etilgan ilmiy ma’lumotlarni umumlashtirib, ushbu murakkab o‘zaro ta’sir yo‘llarini tizimli tahlil qilishga qaratilgan. Maqolada, birinchi navbatda, monotsitlar, neytrofillar, limfotsitlar va makrofaglarning faollashuvida endotelial disfunksiyaning induksiyalovchi roli, shuningdek, yallig‘lanish sitokinlarining (TNF-α, IL-1β, IL-6) hamda kislorod radikallari va azot oksidining muvozanati buzilishining vazifasi tahlii qilinadi [3,4]. Keyinchalik, yallig‘lanish signallarining tutash nuqtasi sifatida NF-κB va NLRP3 inflammasoma kabi molekulyar yo‘llarning faollashishi va ularning hujayra adezyon molekulalari (VCAM-1, ICAM-1) ifodasini oshirish orqali leykotsitlarning tomir devoriga infiltratsiyasini kuchaytirish mexanizmlari ko‘rib chiqiladi [5,6]. Tomir devorining qayta qurilishining yakuniy bosqichida, makrofaglar tomonidan ishlab chiqariladigan matriks metalloproteinazalar (MMP-2, MMP-9) va o‘sish omillarining (TGF-β, PDGF) faolligining oshishi natijasida silliq mushak hujayralarining migratsiyasi va proliferatsiyasi, shuningdek, ekstrasellyular matriksning to‘planishi kabi hodisalar yuzaga keladi, bu esa tomir qattiqligi va stenozining rivojlanishiga olib keladi [7,8]. Ushbu sharh jarayonlarni boshqarishning yangi terapevtik strategiyalarini ishlab chiqish uchun nazariy asos yaratadi, jumladan, aniq molekulyar nishonlarni blokirovka qilish, leykotsit-endotel o‘zaro ta’sirini modulyatsiya qilish va yallig‘lanishga qarshi yangi yondashuvlarni qo‘llash imkoniyatlarini taqdim etadi [9,10].
References
1. Rixsillayevich K. E., Dilshodovich X. H. QONNING HIMOYA FUNKTSIYASI ELEMENTLARINING BIR-BIRIGA ANTAGONISTLARI: ASOSIY REGULYATOR MEXANIZMLAR VA PATOLOGIK OQIBATLAR //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 459-469.
2. Botir J., Hikmatulla K., Muslimaxon J. FACTORS STIMULATE THE PRODUCTION OF HISTAMINASE ENZYME BY EOSINOPHILS //SO ‘NGI ILMIY TADQIQOTLAR NAZARIYASI. – 2025. – Т. 9. – №. 12. – С. 56-65.
3. Faxriddinovna A. N., Dilshod ogli X. H. GOMEOSTAZ VA IMMUNITET YALLIG ‘LANISH JARAYONLARI BILAN MUVOZANATNI TIKLASH MEXANIZMLARI //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 145-153.
4. Faxriddinovna A. N., Dilshod ogli X. H. ENDOKRIN TIZIMDAGI GOMEOSTATIK UZILISHLAR VA ULARNING METABOLIK SINDROMGA OLIB KELUVCHI OQIBATLARI //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 180-188.
5. Faxriddinovna A. N., Dilshod ogli X. H. PSIXOLOGIK HOMEOSTAZ, STRESS, EMOTSIONAL MUVOZANAT VA NEYROPLASTIKLIK O ‘RTASIDAGI ALOQALAR //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 167-179.
6. Faxriddinovna A. N., Dilshod ogli X. H. YOSH O ‘TISHI BILAN GOMEOSTAZNING BUZILISHI ENDOKRIN VA IMMUN TIZIMDAG O ‘ZGARISHLAR //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 154-166.
7. Shuxrat o'g J. N. et al. LEYKOTSITLARNING TARMOQLI IMMUN MONITORINGI UCHUN SUN’IY INTELLEKT ASOSIDAGI YONDASHUVLAR //Latin American journal of education. – 2025. – Т. 5. – №. 7. – С. 107-121.
8. Ravshanovich G. M., Dilshodovich X. H., Asadbek A. SUN’IY INTELLEKT TIZIMLARIDA GOMEOSTATIK TAMOYILLARNI QO ‘LLASH ADAPTIV BOSHQARUV VA O ‘ZINI SOZLASH MODELLARINI ISHLAB CHIQISH //Latin American journal of education. – 2025. – Т. 5. – №. 6. – С. 589-604.
9. Hikmatulla X., Botir J., Marjona A. EOZINOFILLAR TOMONIDAN GISTAMINAZA FERMENTI ISHLAB CHIQARILISHINI STIMULLOVCHI OMILLAR //Научный Импульс. – 2025. – Т. 4. – №. 39. – С. 509-519.
10. Dilshod ogli X. H. et al. SUV-ELEKTROLIT BALANSINING GOMEOSTATIK NAZORATI VA GIDRATATSIYA BUZILISHINING KLINIK OQIBATLARI //Научный Импульс. – 2025. – Т. 4. – №. 39. – С. 533-547.
11. Dilshodovich X. H., Norqulovich K. J. NEUTROFILLARNING YALLIG ‘LANISH JARAYONIDAGI PLASTIKLIK XUSUSIYATLARI VA IMMUN TIZIMDAGI AHAMIYATI //JOURNAL OF INNOVATIONS IN SCIENTIFIC AND EDUCATIONAL RESEARCH. – 2025. – Т. 8. – №. 11. – С. 140-154.
12. Zabixullaevich X. R. et al. TERMOREGULYATSIYADA GOMEOSTAZ ATROF-MUHIT HARORATI O ‘ZGARISHIGA JAVOBAN FIZIOLOGIK MOSLASHUV MEXANIZMLARI //JOURNAL OF INNOVATIONS IN SCIENTIFIC AND EDUCATIONAL RESEARCH. – 2025. – Т. 8. – №. 11. – С. 71-81.
13. Zabixullaevich K. R. et al. Adaptative Changes Of Homeostatic Systems In Response To Stress The Role Of Cortisol And The Sympathetic Nervous System //Emerging Frontiers Library for The American Journal of Medical Sciences and Pharmaceutical Research. – 2025. – Т. 7. – №. 11. – С. 77-83.
14. Faxriddinovna A. N. et al. EOZINOFIL HUJAYRALARINING XEMOTAKSIS OMILLARI //Problems and solutions at the stage of innovative development of science, education and technology. – 2025. – Т. 2. – №. 11. – С. 13-21.
15. Zabixullaevich X. R., Dilshodovich X. H., Elbek A. INSON TANASIDA GOMEOSTAZNING NEYRO-GORMONAL BOSHQARUVI GIPOTALAMUS VA GIPOFIZ O ‘RTASIDAGI O ‘ZARO TA’SIR MEXANIZMLARI //O'ZBEKISTONDA FANLARARO INNOVATSIYALAR VA ILMIY TADQIQOTLAR JURNALI. – 2025. – Т. 4. – №. 46. – С. 164-176.
16. Faxriddinovna A. N. et al. EOZINOFIL FAGASITOZ QILISH MEXANIZMLARI //Advanced methods of ensuring the quality of education: problems and solutions. – 2025. – Т. 2. – №. 11. – С. 44-54.
17. Shokhijakhon A., Hikmatulla K., Shokhrukh R. Factors Of Chemotaxis Of Eosinophil Cells //Emerging Frontiers Library for The American Journal of Medical Sciences and Pharmaceutical Research. – 2025. – Т. 7. – №. 11. – С. 19-24.
18. Dadajonovna M. G., Hikmatulla K. Mechanisms Of Eosinophylic Phagocytosis //Emerging Frontiers Library for The American Journal of Medical Sciences and Pharmaceutical Research. – 2025. – Т. 7. – №. 11. – С. 12-18.
19. Vahob ogli B. O. et al. O'TKIR RESPIRATOR VIRUSLI INFEKSIYALARNI YURAKKA TASIRI //AMERICAN JOURNAL OF APPLIED MEDICAL SCIENCE. – 2025. – Т. 3. – №. 1. – С. 389-395.
20. Vaxob ogli B. O., Dilshodovich X. H. KO'P QIRRALI PATOLOGIK JARAYON SIFATIDA GIPERGLIKEMIYANING SIYDIK PUFAGI VA PROSTATA BEZIGA TA’SIRI //Latin American journal of education. – 2025. – Т. 5. – №. 6. – С. 534-549.
21. Vaxob ogli B. O., Dilshodovich X. H. GIPERGLIKEMIK HOLATDAGI URUG ‘PUFAKCHALARI VA PROSTATA BEZINING MORFOLOGIYASI //Latin American journal of education. – 2025. – Т. 5. – №. 6. – С. 550-563.
22. Mamadalieva O., Tilyabov I. Morphometric changes in the renal tissue of offspring rats born under experimental diabetes mellitus conditions on days 3, 60, and 90 //INTEGRATION OF EDUCATION AND SCIENCE: GLOBAL CHALLENGES AND SOLUTIONS. – 2025. – Т. 1. – №. 1. – С. 271-274.
23. Usmanov R. J., Sh A. D., Tilyabov I. A. MORPHOLOGICAL CHARACTERISTIC CHANGES OF THE KIDNEY TISSUE OF OFFSPRING OF RATS BORN ON THE BACKGROUND OF DIABETES MELLITUS WITH STREPTOCYAZINE //Art of Medicine. International Medical Scientific Journal. – 2023. – Т. 3. – №. 1.
24. Тилябов И. А. ОНТОГЕНЕЗНИНГ ТУРЛИ ДАВРЛАРИДА СТРЕПТОЗОТОСИНЛИ ҚАНДЛИ ДИАБЕТ ФОНИДА ТУҒИЛГАН КАЛАМУШЛАР АВЛОДИ БУЙРАК ТЎҚИМАСИНИНГ МОРФОЛОГИК ЎЗГАРИШЛАРИ //Журнал гуманитарных и естественных наук. – 2023. – №. 3 [2]. – С. 159-166.
25. Bahodirovna A. D. Tension headaches and psychovegetative disorders //Web of Medicine: Journal of Medicine, Practice and Nursing. – 2023. – Т. 1. – №. 1. – С. 27-29.
26. Пулатов Х. Х., Усманов Р. Д., Ахмедова Д. Б. СОВРЕМЕННЫЕ АСПЕКТЫ ЭПИДЕМИОЛОГИИ И ЗНАЧИМОСТИ САХАРНОГО ДИАБЕТА //Вестник Ассоциации Пульмонологов Центральной Азии. – 2025. – Т. 12. – №. 7. – С. 257-261.
27. Шотурсунова М. А., Ахмедова Д. Б. ДИНАМИКА МЕТАБОЛИЧЕСКИХ ПОКАЗАТЕЛЕЙ И УРОВНЯ HBA₁C В СЫВОРОТКЕ КРОВИ ПРИ АЛЛОКСАН-ИНДУЦИРОВАННОМ ДИАБЕТЕ У ЭКСПЕРИМЕНТАЛЬНЫХ ЖИВОТНЫХ //Medical journal of Uzbekistan. – 2025. – Т. 1. – №. 2. – С. 311-316.
28. Sayfutdinova Z. A. et al. FLAVONOIDLARNING BIOLOGIK FAOLLIGI VA ULARNING GIPOLIPIDEMIK PREPARATLAR SIFATIDA QO'LLANILISHI IMKONIYATLARI //Лучшие интеллектуальные исследования. – 2025. – Т. 44. – №. 5. – С. 33-41.
