ASSOCIATION BETWEEN KAPPA FREE LIGHT CHAINS, DISABILITY, AND MRI FINDINGS IN PREDICTING THE COURSE OF MULTIPLE SCLEROSIS
Keywords:
MRI diagnostics, paramagnetic rim lesions, prognosis, multiple sclerosis.Abstract
The search for reliable biomarkers reflecting intrathecal immunoglobulin synthesis and predicting the course of multiple sclerosis (MS) remains one of the priority tasks of modern neuroimmunology. Kappa free light chains (κ-FLC) in the cerebrospinal fluid are considered a sensitive quantitative marker of B-cell activity and an alternative to oligoclonal bands. Their potential association with the level of disability and neuroimaging characteristics of the disease requires further clarification.
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